Arminja Kettenbach
Associate Professor of Biochemistry and Cell Biology
Member Norris Cotton Cancer Center
E-mail: Arminja.N.Kettenbach@dartmouth.edu
Education: Diplom (equivalent M. Sc.) Eberhard-Karls University Tübingen, Germany
Dr. rer. nat (summa cum laude, equivalent Ph.D.) Eberhard-Karls University, Tübingen, Germany and Harvard Medical School, Boston
Bio: Arminja received her Diploma and Ph.D from Eberhard-Karls University, Tübingen, Germany. She conducted her graduate student work under the supervision of Dr. Frank McKeon at Harvard Medical School in collaboration with Eberhard-Karls University. Her graduate work was focused on mechanisms of cell differentiation and division. She then pursued a postdoctoral fellowship in the field of mass spectrometry-based proteomics in the laboratory of Dr. Scott Gerber at the Geisel School of Medicine at Dartmouth, where she conducted large-scale quantitative chemical phosphoproteomics experiments using small molecule inhibitors to identify substrates of the mitotic kinases Polo-like kinase 1, Aurora kinase A, and Aurora kinase B. Furthermore, she developed a more efficient workflow for phosphopeptide enrichment and a new approach for the identification of protein kinase motifs using mass spectrometry.
As an independent investigator, Arminja is interested in determining how protein dephosphorylation contributes to faithful chromosome segregation, mitotic progression, and maintenance of genomic stability. Using biochemical and cell biological approaches in combination with microscopy and quantitative proteomics, the lab investigates the role of protein phosphatases in mitotic progression, their regulation, substrate targeting mechanisms, and kinase counter-action.
