Publications


2018
Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.
Kumar GS, Choy MS, Koveal DM, Lorinsky MK, Lyons SP, Kettenbach AN, Page R, Peti W. Science Advances 2018. [pubmed]
A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.
Lyons SP, Jenkins NP, Nasa I, Choy MS, Adamo ME, Page R, Peti W, Moorhead GB, Kettenbach AN. Molecular and Cellular Proteomics 2018. [pubmed]
Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.
Zhao Y, Zurawel AA, Jenkins NP, Duennwald ML, Cheng C, Kettenbach AN, Supattapone S. Scientific Reports 2018. [pubmed]
Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.
Nasa I, Rusin SF, Kettenbach AN, Moorhead GB. Science Signaling 2018. [pubmed]
Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.
Kettenbach AN, Schlosser KA, Lyons SP, Nasa I, Gui J, Adamo ME, Gerber SA. Science Signaling 2018. [pubmed]
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
Shee K, Yang W, Hinds JW, Hampsch RA, Varn FS, Traphagen NA, Patel K, Cheng C, Jenkins NP, Kettenbach AN, Demidenko E, Owens P, Faber AC, Golub TR, Straussman R, Miller TW. Journal of Experimental Medicine 2018. [pubmed]
Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.
Lee ME, Rusin SF, Jenkins N, Kettenbach AN, Moseley JB. Current Biology 2018. [pubmed]

2017
Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics.
Rusin SF, Adamo ME, Kettenbach AN. Frontiers in Cell and Developmental Biology 2017.  [pubmed]
PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.
Choy MS, Swingle M, D’Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W. Journal od the American Chemical Society 2017. [pubmed]
Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA. Elife 2017. [pubmed]
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Pallesen J, Wang N, Corbett KS, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong WP, Andres EL, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS. PNAS 2017. [pubmed]
A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
Cullati SN, Kabeche L, Kettenbach AN, Gerber SA. Journal of Cell Biology 2017. [pubmed]
HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex.
Orr A, Song H, Rusin SF, Kettenbach AN, Wickner W. Molecular Biology of the Cell 2017. [pubmed]

2016
Application of RNAi-induced gene expression profiles for prognostic prediction in breast cancer.
Wang Y, Mark KM, Ung MH, Kettenbach A, Miller T, Xu W, Cheng W, Xia T, Cheng C. Genome Medicine 2016. [pubmed]
Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Co-Repressor of Neurospora crassa.
Olivares-Yañez C, Emerson J, Kettenbach A, Loros JJ, Dunlap JC, Larrondo LF. Genetics 2016. [pubmed]
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics.
Petrone A, Adamo ME, Cheng C, Kettenbach AN. Molecular and Cellular Proteomics 2016. [pubmed]
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Chattopadhyay D, Swingle MR, Salter EA, Wood E, D’Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, Banerjee S, Forbes D, Wierzbicki A, Honkanen RE. Biochemical Pharmacology 2016. [pubmed]
Phosphorylation regulates Id2 degradation and mediates the proliferation of neural precursor cells.
Sullivan JM, Havrda MC, Kettenbach AN , Paolella BR, Zhang Z, Gerber SA, Israel MA. Stem Cells 2016. [pubmed]

2015
Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.
Rusin SF, Schlosser KA, Adamo ME, Kettenbach AN. Science Signaling 2015. [pubmed]
Analysis of the Candida albicans Phosphoproteome.
Willger SD, Liu Z, Olarte RA, Adamo ME, Stajich JE, Myers LC, Kettenbach AN, Hogan DA. Eukaryot Cell 2015. [pubmed]
Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN, Deng L, Wu Y, Baldissard S, Adamo ME, Gerber SA, Moseley JB. Molecular and Cellular Proteomics 2015. [pubmed]

2014
SPECHT – Single-stage phosphopeptide enrichment and stable-isotope chemical tagging: Quantitative phosphoproteomics of insulin action in muscle.
Kettenbach AN, Sano H, Keller SR, Lienhard GE, Gerber SA. Journal of Proteomics 2014. [pubmed]
Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion.
Orr A, Wickner W, Rusin SF, Kettenbach AN, Zick M. Molecular Biology of the Cell 2014. [pubmed]
Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.
Wang B, Kettenbach AN, Gerber SA, Loros JJ, Dunlap JC. PLoS Genetics 2014. [pubmed]
Dueling kinases regulate cell size at division through the SAD kinase Cdr2.
Deng L, Baldissard S, Kettenbach AN, Gerber SA, Moseley JB. Current Biology 2014. [pubmed]

Previous
Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
Soundararajan M, Roos AK, Savitsky P, Filippakopoulos P, Kettenbach AN, Olsen JV, Gerber SA, Eswaran J, Knapp S, Elkins JM. Structure 2013. [pubmed]
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D, Kettenbach AN, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. PLoS One 2013. [pubmed]
Rapid determination of multiple linear kinase substrate motifs by mass spectrometry.
Kettenbach AN, Wang T, Faherty BK, Madden DR, Knapp S, Bailey-Kellogg C, Gerber SA. 
Chemistry and Biology 2012. [pubmed]
Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.

Hood EA, Kettenbach AN, Gerber SA, Compton DA.
 Molecular Biology of the Cell 2012. [pubmed]
MMFPh: a maximal motif finder for phosphoproteomics datasets.
Wang T, Kettenbach AN, Gerber SA, Bailey-Kellogg C. 
Bioinformatics 2012. [pubmed]
Increasing phosphoproteomic coverage through sequential digestion by complementary proteases.
Gilmore JM, Kettenbach AN, Gerber SA. Analytical and Bioanalytical Chemistry 2012. [pubmed]
Rapid and reproducible single-stage phosphopeptide enrichment of complex peptide mixtures: application to general and phosphotyrosine-specific phosphoproteomics experiments.
Kettenbach AN, and Gerber SA. Analytical Chemistry 2011. [pubmed]
Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.
Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT.
 PLoS One 2011. [pubmed]
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells.
Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA. Science Signaling 2011. [pubmed]
Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
Sano H, Peck GR, Kettenbach AN, Gerber SA, Lienhard GE. J Biological Chemistry 2011. [pubmed]
Absolute quantification of protein and post-translational modification abundance with stable isotope-labeled synthetic peptides.
Kettenbach AN, Rush J, Gerber SA. Nature Protocols 2011. [pubmed]
Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.
Yang A, Zhu Z, Kettenbach AN, Kapranov P, McKeon F, Gingeras TR, Struhl K. PLoS One 2010. [pubmed]
Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
Lyons PD, Peck GR, Kettenbach AN, Gerber SA, Roudaia L, Lienhard GE. Bioscience Reports 2009. [pubmed]
Quantitative proteomics reveals a dynamic interactome and phase-specific phosphorylation in the Neurospora circadian clock.
Baker CL, Kettenbach AN, Loros JJ, Gerber SA, Dunlap JC. Molecular Cell 2009. [pubmed]
The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126.
Gerber SA, Kettenbach AN, Rush J, Gygi SP. Methods in Molecular Biology 2007. [pubmed]
p63 protects the female germ line during meiotic arrest.
Suh EK, Yang A, Kettenbach AN, Bamberger C, Michaelis AH, Zhu Z, Elvin JA, Bronson RT, Crum CP, McKeon F. Nature 2006. [pubmed]
Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway.
Chien W, Tidow N, Williamson EA, Shih LY, Krug U, Kettenbach AN, Fermin AC, Roifman CM, Koeffler HP. J Biological Chemistry 2003. [pubmed]
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