Publications

Modulation of Circadian Gene Expression and Metabolic Compensation by the RCO-1 Co-Repressor of Neurospora crassa.
Olivares-Yañez C, Emerson J, Kettenbach A, Loros JJ, Dunlap JC, Larrondo LF. Genetics. 2016 Jul 22. [pubmed]
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics.
Petrone A, Adamo ME, Cheng C, Kettenbach AN. Mol Cell Proteomics. 2016 July 15. [pubmed]
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Chattopadhyay D, Swingle MR, Salter EA, Wood E, D’Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, Banerjee S, Forbes D, Wierzbicki A, Honkanen RE. Biochem. Pharmacol. 2016 Jun 1. [pubmed]
Phosphorylation regulates Id2 degradation and mediates the proliferation of neural precursor cells.
Sullivan JM, Havrda MC, Kettenbach AN , Paolella BR, Zhang Z, Gerber SA, Israel MA. Stem Cells. 2016 Jan 12. [pubmed]
Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.
Rusin SF, Schlosser KA, Adamo ME, Kettenbach AN. Science Signaling. 2015 Oct 13;8(398):rs12. [pubmed]
Analysis of the Candida albicans Phosphoproteome.
Willger SD, Liu Z, Olarte RA, Adamo ME, Stajich JE, Myers LC, Kettenbach AN, Hogan DA. Eukaryot Cell. 2015 May;14(5):474-85. [pubmed]
Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN, Deng L, Wu Y, Baldissard S, Adamo ME, Gerber SA, Moseley JB. Mol Cell Proteomics. 2015 May;14(5):1275-87. [pubmed]
SPECHT – Single-stage phosphopeptide enrichment and stable-isotope chemical tagging: Quantitative phosphoproteomics of insulin action in muscle.
Kettenbach AN, Sano H, Keller SR, Lienhard GE, Gerber SA. J Proteomics. 2014 Nov 9;114C:48-60. [pubmed]
Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion.
Orr A, Wickner W, Rusin SF, Kettenbach AN, Zick M. Mol Biol Cell. 2014 Nov 19. [pubmed]
Neurospora WC-1 recruits SWI/SNF to remodel frequency and initiate a circadian cycle.
Wang B, Kettenbach AN, Gerber SA, Loros JJ, Dunlap JC. PLoS Genet. 2014 Sep 25;10(9):e1004599. [pubmed]
Dueling kinases regulate cell size at division through the SAD kinase Cdr2.

Deng L, Baldissard S, Kettenbach AN, Gerber SA, Moseley JB. Curr Biol. 2014 Feb 17;24(4):428-33. [pubmed]

Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
Soundararajan M, Roos AK, Savitsky P, Filippakopoulos P, Kettenbach AN, Olsen JV, Gerber SA, Eswaran J, Knapp S, Elkins JM. Structure. 2013 Jun 4;21(6):986-96. [pubmed]
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
McNamara CR, Ahuja R, Osafo-Addo AD, Barrows D,Kettenbach AN, Skidan I, Teng X, Cuny GD, Gerber S, Degterev A. PLoS One. 2013;8(3):e56576. [pubmed]
Rapid determination of multiple linear kinase substrate motifs by mass spectrometry.
Kettenbach AN, Wang T, Faherty BK, Madden DR, Knapp S, Bailey-Kellogg C, Gerber SA. 
Chem Biol. 2012 May 25;19(5):608-18. [pubmed]
Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.

Hood EA, Kettenbach AN, Gerber SA, Compton DA.
 Mol Biol Cell. 2012 Jun; 23(12):2264-74. [pubmed]
MMFPh: a maximal motif finder for phosphoproteomics datasets.
Wang T, Kettenbach AN, Gerber SA, Bailey-Kellogg C. 
Bioinformatics. 2012 Jun 15;28(12):1562-70. [pubmed]
Increasing phosphoproteomic coverage through sequential digestion by complementary proteases.
Gilmore JM, Kettenbach AN, Gerber SA. Anal Bioanal Chem. 2012 Jan; 402(2):711-20. [pubmed]
Rapid and reproducible single-stage phosphopeptide enrichment of complex peptide mixtures: application to general and phosphotyrosine-specific phosphoproteomics experiments.
Kettenbach AN, Gerber SA. Anal Chem. 2011 Oct 15;83(20):7635-44. [pubmed]
Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.
Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT.
 PLoS One. 2011;6(7):e22862. [pubmed]
Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells.
Kettenbach AN, Schweppe DK, Faherty BK, Pechenick D, Pletnev AA, Gerber SA. Sci Signal. 2011 Jun 28;4(179):rs5. [pubmed]
Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
Sano H, Peck GR, Kettenbach AN, Gerber SA, Lienhard GE. J Biol Chem. 2011 May 13; 286(19):16541-5. [pubmed]
Absolute quantification of protein and post-translational modification abundance with stable isotope-labeled synthetic peptides.
Kettenbach AN, Rush J, Gerber SA. Nat Protoc. 2011 Feb; 6(2):175-86. [pubmed]
Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.
Yang A, Zhu Z, Kettenbach AN, Kapranov P, McKeon F, Gingeras TR, Struhl K. PLoS One. 2010 Jul 14; 5(7): e11572. [pubmed]
Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
Lyons PD, Peck GR, Kettenbach AN, Gerber SA, Roudaia L, Lienhard GE. Biosci Rep. 2009 Aug; 29(4): 229-35. [pubmed]
Quantitative proteomics reveals a dynamic interactome and phase-specific phosphorylation in the Neurospora circadian clock.
Baker CL, Kettenbach AN, Loros JJ, Gerber SA, Dunlap JC. Mol Cell. 2009 May 15; 34(3): 354-63. [pubmed]
The absolute quantification strategy: application to phosphorylation profiling of human separase serine 1126.
Gerber SA, Kettenbach AN, Rush J, Gygi SP. Methods Mol Biol. 2007; 359: 71-86. [pubmed]
p63 protects the female germ line during meiotic arrest.
Suh EK, Yang A, Kettenbach AN, Bamberger C, Michaelis AH, Zhu Z, Elvin JA, Bronson RT, Crum CP, McKeon F. Nature. 2006 Nov 30; 444(7119): 624-8. [pubmed]
Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway.
Chien W, Tidow N, Williamson EA, Shih LY, Krug U, Kettenbach AN, Fermin AC, Roifman CM, Koeffler HP. J Biol Chem. 2003 Jul 25; 278(30): 27413-20. [pubmed]
Top